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Wikipedia - Torsades de pointes

Torsades de pointes
Classification and external resources
DiseasesDB 29252
eMedicine med/2286 emerg/596
MeSH D016171

Torsades de pointes, or simply torsades is a French term that literally means "twisting of the points." It was first described by Dessertenne in 1966[1] and refers to a specific variety of ventricular tachycardia that exhibits distinct characteristics on the electrocardiogram (ECG).

Contents

[edit] Presentation

The ECG reading in torsades demonstrates a rapid, polymorphic ventricular tachycardia with a characteristic twist of the QRS complex around the isoelectric baseline. It is also associated with a fall in arterial blood pressure, which can produce fainting. Although torsades de pointes is a rare ventricular arrhythmia, it can degenerate into ventricular fibrillation, which will lead to sudden death in the absence of medical intervention. Torsades de pointes is associated with long QT syndrome, a condition whereby prolonged QT intervals are visible on the ECG. Long QT intervals predispose the patient to an R-on-T phenomenon, where the R wave representing ventricular depolarization occurs simultaneously to the relative refractory period at the end of repolarization (represented by the latter half of the T-wave). An R-on-T can initiate torsades.

Characteristic tracing showing the "twisting" (blue line) of a torsade de pointes

[edit] Characteristics

[edit] Causes

Long QT syndrome can either be inherited as congenital mutations of ion channels carrying the cardiac impulse/action potential or acquired as a result of drugs that block these cardiac ion currents.

Common causes for torsades de pointes include diarrhea, hypomagnesemia and hypokalemia. It is commonly seen in malnourished individuals and chronic alcoholics. Drug interactions such as erythromycin or moxifloxacin, taken concomitantly with inhibitors like nitroimidazole, dietary supplements, and various medications like methadone, lithium, tricyclic antidepressants or phenothiazines may also contribute. It can also be the side effect of some anti-arrhytmic medications such as sotalol, procainamide and quinidine.

Factors that are associated with an increased tendency toward torsades de pointes include:

Lead II electrocardiogram showing Torsades being shocked by an Implantable cardioverter-defibrillator back to the patients baseline cardiac rhythm.

[edit] Treatment

Treatment is directed at withdrawal of the offending agent, infusion of magnesium sulfate,[2][3] antiarrhythmic drugs, and electrical therapy as needed.

Because of the polymorphic nature of torsades de pointes, synchronized cardioversion may not be possible, and the patient may require an unsynchronized shock (or defibrillation).

[edit] History and terminology

The French term is largely due to the fact that the phenomenon was originally described in a French medical journal by Dessertenne in 1966, when he observed this cardiac rhythm disorder in an 80-year-old female patient with complete intermittent atrioventricular block.

[edit] References

  1. ^ Dessertenne F (1966). "La tachycardie ventriculaire a deux foyers opposes variables." (in French). Arch Mal Coeur Vaiss. 59 (2): 263–72. PMID 4956181. 
  2. ^ Hoshino K, Ogawa K, Hishitani T, Isobe T, Eto Y (October 2004). "Optimal administration dosage of magnesium sulfate for torsades de pointes in children with long QT syndrome". J Am Coll Nutr 23 (5): 497S–500S. PMID 15466950. http://www.jacn.org/cgi/pmidlookup?view=long&pmid=15466950. 
  3. ^ Hoshino K, Ogawa K, Hishitani T, Isobe T, Etoh Y (April 2006). "Successful uses of magnesium sulfate for torsades de pointes in children with long QT syndrome". Pediatr Int 48 (2): 112–7. doi:10.1111/j.1442-200X.2006.02177.x. PMID 16635167. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1328-8067&date=2006&volume=48&issue=2&spage=112. 
Retrieved from "http://en.wikipedia.org/wiki/Torsades_de_pointes"

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Torsades de pointes".

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